임준형 약력
Research Interest
1 표적 단백질 규명 및 작용기전 연구 (Target Protein Identification and Mode-of-Action Studies)
2 화학적 면역조절 및 면역 재프로그래밍 연구 (Chemical Immunomodulation and Immune Reprogramming)
3 표적 단백질 분해 기술 연구 (Targeted Protein Degradation; PROTAC & Molecular Glue Technologies)
4 조직·종양·면역 특이적 PROTAC 플랫폼 구축 (Tissue-, Tumor-, and Immune–Specific PROTAC Platforms)
5 단백질 분해의 시공간적 정밀 제어 기술 개발 (Spatiotemporal Control of Protein Degradation)
Education
학사 2016 서울대학고 수의과대학 수의학사 (수의학전공)
박사 2023 서울대학교 자연과학대학 이학박사 (화학생물학 전공)
Selected Publications
1. Investigation of proteome-tetrazine reactivity for a highly selective tetrazine ligation in live cells. Park, J.†; Hahm, J.†; Yim, J.†(*); Lee, H.; Hwang, H. M.; Lee, S.; Park, J.-Y; Arun, V.; Kumar, G. J.; Cho, H.; Park, H.; Lee, M.; Lee, J.; Eom, H.; Song, W. J.; Lee, S.; Kim, E.; Park, J. ACS Cent. Sci. 2025, 11, 878–889. (†: equally contributed)
2. Fragment-based approaches to discover ligands for tissue-specific E3 ligases. Yim, J.(*); Kim, S.; Lee, H.H.; Chung, J.S.; Park, J. Expert. Opin. Drug. Discov. 2024, 19, 1471–1484.
3. Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation. Yim, J.(*); Park, J.; Kim, G.; Lee, H.H.; Chung, J.S.; Jo, A.; Koh, M.; Park, J. ChemMedChem. 2024, 19, e202400326.
4. Inflachromene ameliorates Parkinson’s disease by targeting Nrf2-binding Keap1. Yim, J.(*); Hwang, Y.S.; Lee, J.-J.; Kim, J.H.; Beak, J.Y.; Jeong J.Y.; Choi, Y.; Jin, B.K.; Park, S.B. Chem. Sci. 2024, 15, 3588–3595.
5. Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy. Cho, W.†; Won, S.†; Choi, Y.; Yi, S.; Park, J.B.; Park, J.-G.; Kim, C.E.; Narayana, C.; Kim, J.H.; Yim, J.(*); Choi, Y.I.; Lee, D.-S.; Park, S.B. Angew. Chem. Int. Ed. 2023, 62, e202300978. (†: equally contributed)
6. Inhibition of ACE2‐Spike Interaction by an ACE2 Binder Suppresses SARS‐CoV‐2 Entry. Shin, Y.- H.†; Jung, K.†; Lee, J.; Lee, H.J.; Yim, J. (*); Kim, J.; Kim, S.; Park, S. B. Angew. Chem. Int. Ed. 2022, 61, e202115695. (†: equally contributed)
7. Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuro inflammatory agents. Yim, J.(*); Lee, J.; Yi, S.; Koo, J.Y.; Oh, S.; Park, H.; Kim, S.S.; Bae, M.A.; Park, J.; Park, S.B. Exp. Mol. Med. 2022, 54, 2200–2209.
8. Label-free Target Identification Reveals the Anticancer Mechanism of a Rhenium Isonitrile Complex. Yim, J.(*); Park, S.B. Front. Chem. 2022, 10, 850638.
9. Improved Th17 Selectivity of α-Galactosylceramide via Noncovalent Interactions with Diether Moiety. Hwang, Y.S.†; Yim, J.†(*); Song, H.†; Park, S. B. ACS Med. Chem. Lett. 2019, 10, 720–725. (†: equally contributed)
