장민선 약력
■ 세부전공 :
1. Molecular mechanisms of anticancer drug resistance
2. Discovery and development of novel plant-based estrogen replacement therapy
3. Targeting FYN as a regulator of palbocilib resistance in breast cancer
4. Roles of transcription factors in acquired drug resistance in breast cancer
5. Molecular mechanism of drug-drug/food/herb interactions
■ 학력
학사 1991 숙명여자대학교 약학사
석사 1993 숙명여자대학교 약품제조화학
박사 2000 University of Illinois at Chicago 의약화학/분자독성학
박사후연수 2001-2002 Northwestern University Medical School
연구교수 2003-2005 University of Illinois at Chicago, College of Pharmacy
선임연구원 2005-2008 LG화학(구, LG생명과학)
■ 경력 :
2001-2003 Research fellow, Feinberg College of Medicine, Northwestern University, Chicago, IL, USA
2003-2005 Research assistant professor, College of Pharmacy, University of Illinois at Chicago, USA
2005-2008 Sr. Research scientist, LG Life Sciences, Korea
2008-2010 Instructor, Department of Biological Sciences, Sookmyung Women's University, Seoul, Korea
■ Research Interest
l Mechanism on drug-resistance in breast cancer
l Role of drug metabolizing enzymes on estrogen receptor-signaling pathways
l Discovery and development of phytoestrogens
l Evaluation of drug-herb interaction via hepatic metabolism
■ Funding
l 미래창조과학부/한국연구재단/과학기술국제화사업 - 공동연구원 - 2013.10-2018.09
l 농림축산식품부/농림수산식품기술기획평가원/고부가가치식품기술개발사업 - 책임연구원 - 2016.07-2019.06
l 미래창조과학부/한국연구재단/이공분야 기초 중견연구자지원사업 - 책임연구원 - 2016.06-2019.05
■ Publications
1. Minsun Chang* (2024) Current Methodologies of biomarker-based Diagnosis for Alzheimer’s disease Paving the Path for Early Detection of Disease. Journal of the Pharmaceutical Society of Korea (Yakhak Hoeji), 68, 409-428.
2. Jin-Hee Kim, Jimin Lee, Hyesoo Jeong, Mi Seo Bang, Jin-Hyun Jeong, and Minsun Chang* (2021) Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol O-Methyltransferase Modulates 4- Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells, Molecules, 26, 2060.
3. Sehyun Oh, Youngup Cho, Minsun Chang*, Synghyouk Park*, and Hyuknam Kwon* (2021) Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation, Metabolites, 11, 480.
4. Byoung Ha An, Hyesoo Jeong, Jin-Hee Kim, Sujeong Park, Him-Hyun Jeong, Min Jung Kim, and Minsun Chang* (2019) Estrogen Receptor-Mediated Transcriptional Activities of Spent Coffee Grounds and Spent Coffee Grounds Compost, and Their Phenolic Acid Constituents, Journal of Agricultural and Food Chemistry, 67, 8649-8659.
5. Hyesoo Jeong, Jimin Lee, Soolim Kim, Sujeong Park, Hwasun Yang, Byoung Ha An, Chang Young Jang, Hyun Cheol Jeong, Sung-Jin Lee, Sun Lim Kim, Wood Duck Seo, Johann Sohn, and Minsun Chang* (2019) Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue- Specific Modulator, Journal of Medicinal Food, 22(2), 186-195.
6. Hyesoo Jeong, Soolin Kim, Mi-yeon Kim,Jimin Lee, Byoung Ha An, Hee-Doo Kim, Hyungyoung Jeong, Yun Seon Song, and Minsun Chang* (2018) Inhibitory and Inductive Effects of Opuntia ficus indica Extract and Its Flavonoid Constituents on Cytochrome P450s and UDP- Glucuronosyltransferases, International Journal of Molecular Sciences, 19, 3400.
7. Hyesoo Jeong, Jimin Lee, Soolin Kim, Yoo Yeon Yeo, Hyunyoung So, Honghua Wu, Yun Seon Song, Chang Young Jang, Hee-Doo Kim, Min Jung Kim, and Minsun Chang* (2018) Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP- Glucuronosyltransferases. Molecules, 23, 1542.
8. Hyesoo Jeong, Soolin Kim, Jimin Lee, Jin Young Park, Wenmei Zhou, Xiyuan Liu, So Dam Kim, Yun Seon Song, Chang Young Jang, Sei-Ryang Oh, Sangho Choi, and Minsun Chang* (2017) Characterization of phase I and phase II hepatic metabolism and reactive intermediates of Larrea nitida Cav. and its lignan compounds. Phytotherapy Research, 31, 140-151.
9. Boung Ha An, Hyesoo Jeong, Wenmei Zhou, Xiyuan Liu, Soolin Kim, Chang Young Jang, Hyun-Sook Kim, Johann Sohn, Hy-Jin Park, Na-Hye Song, Cheol Yi Hong, and Minsun Chang* (2016) Evaluation of the biological activity of Opuntia ficus indica as a tissue- and estrogen receptor subtype-selective modulator. Phytotherapy Research, 30, 971-980.
■ 재직기간 : 2011.03 ~ 현재
